Key result
A 12-week therapy with a fixed combination of perindopril and amlodipine achieved target blood pressure in 100% of patients with hypertension and type 2 diabetes.
Why the study?
Does a fixed combination of perindopril and amlodipine improve central aortic pressure and markers of target organ damage in patients with stage III arterial hypertension and type 2 diabetes?
Does a fixed combination of perindopril and amlodipine improve central aortic pressure and markers of target organ damage in patients with stage III arterial hypertension and type 2 diabetes?
A 12-week treatment with a fixed combination of perindopril and amlodipine improved central aortic pressure, arterial stiffness, and markers of renal and cardiac damage in patients with severe hypertension and type 2 diabetes.
Answers are grounded in this paper and cite their sources.
May support central pressure and organ damage improvements in hypertensive diabetes; hypothesis-generating, needs randomized confirmation.
Actuality: the contribution of changes in central aortic pressure (CAP) to target organ damage and the effect of a fixed combination of perindopril with arnolate with amlodipine besylate on these parameters in patients with arterial hypertension (AH) and type 2 diabetes (DM) has not been studied. Objective: to reveal the relationship between the main indicators of CAP and the damage of target organs (vessels, kidneys and heart) in patients with AH and type 2 diabetes; assess the organoprotective properties of a 12-week therapy with a fixed combination of perindopril arginate with amlodipine besylate in this category of patients. Materials and methods: 30 patients with AH stage III and DM at the age of 45 to 65 years were examined. The indicators of CAP were determined by Vasotens 24 software (“Petr Telegin” LLC, Russia). The structural and functional state of the myocardium was assessed echocardiographically with a Doppler sensor. The pulse wave velocity (PWV) was measured with Polyspectr 8/E apparatus (Neurosoft, Russia). To evaluate the kidney function, the glomerular filtration rate (GFR) was calculated, and albumin excretion in the urine was determined. A fixed combination of perindopril arginine / amlodipine besylate was administered for 12 weeks. Results: 12-week therapy was accompanied by the achievement of target values of blood pressure in 100% of patients, a decrease in office systolic and diastolic blood pressure. There was a significant improvement in indicators of CAP, which was accompanied by a statistically significant decrease in PWV in vessels of the elastic and muscular type, an improvement in the functional state of the kidneys: a decrease in the level of the albumin/creatinine ratio of urine, an increase in rGFR, by a significant decrease in the left ventricular myocardium index. Conclusion: admission of a fixed combination of perindopril and amlodipine in patients with AH in combination with type 2 diabetes for 12 weeks is accompanied by reliable cardio, nephroprotective and endotheliotropic effects, statistically significantly reduces systolic and diastolic CAP, augmentation index in daytime and night hours, leads to a significant reduction of rigidity of the main arteries.
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Стаценко et al. (2018) studied Arterial hypertension and type 2 diabetes mellitus (n=30). Fixed combination of perindopril arginate and amlodipine besylate was evaluated on Achievement of target values of blood pressure. A 12-week therapy with a fixed combination of perindopril and amlodipine achieved target blood pressure in 100% of patients with hypertension and type 2 diabetes.
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