Why the study?
Is the maximum rate of oxygen consumption (VO2max) related to succinate dehydrogenase (SDH) activity in skeletal muscle fibres of chronic heart failure patients?
Population
20 subjects total: 14 chronic heart failure (CHF) patients (NYHA class I-III) and 6 controls.
Comparison
Incremental bicycle ergometer test to determine… vs Healthy controls (n=6)
Design
Cross-sectional
Authors
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May indicate peripheral oxidative capacity limits exercise tolerance in CHF; hypothesis-generating for muscle-targeted interventions.
Is the maximum rate of oxygen consumption (VO2max) related to succinate dehydrogenase (SDH) activity in skeletal muscle fibres of chronic heart failure patients?
In patients with chronic heart failure, maximum oxygen consumption correlates strongly with skeletal muscle oxidative capacity (SDH activity), suggesting peripheral muscle factors limit exercise capacity.
Bekedam et al. (2003) studied this question.
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