Effects of amrinone on myocardial energy metabolism and hemodynamics in patients with severe congestive heart failure due to coronary artery disease.
Why the study?
Does amrinone improve hemodynamics and alter myocardial oxygen consumption in patients with severe congestive heart failure due to coronary artery disease?
Population
9 patients with severe congestive heart failure secondary to coronary artery disease
Comparison
Amrinone 2.5 mg/kg i.v. over 1 hour vs Baseline (pre-treatment measurements)
Design
Case_series
Follow-up
1 hour
Authors
Discussion
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Member takes
Implication
May support amrinone for hemodynamics with lower myocardial O2 use in severe HF; hypothesis-generating, needs controlled trials.
Structured PICO
Does amrinone improve hemodynamics and alter myocardial oxygen consumption in patients with severe congestive heart failure due to coronary artery disease?
P
Population
9 patients with severe congestive heart failure secondary to coronary artery disease
I
Intervention
Amrinone 2.5 mg/kg i.v. over 1 hour
C
Comparator
Baseline (pre-treatment measurements)
O
Outcome
Hemodynamic, myocardial metabolic, and ECG responses (including myocardial oxygen consumption and coronary blood flow)surrogate
Intravenous amrinone improves hemodynamics while reducing myocardial oxygen consumption and coronary blood flow in patients with severe heart failure due to coronary artery disease.
Cite This Study
Benotti et al. (1980) studied this question.