What question did this study set out to answer?

This study aims to investigate the prognostic importance of silent myocardial ischemia during exercise regarding the risk of stroke and cardiovascular diseases in asymptomatic men.

July 1, 2003StrokeOpen Access

Association of Exercise-Induced, Silent ST-Segment Depression With the Risk of Stroke and Cardiovascular Diseases in Men

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Why the study?

Does exercise-induced silent myocardial ischemia predict the risk of stroke and cardiovascular disease death in asymptomatic middle-aged men?

Population

1726 middle-aged men with no history of stroke, coronary heart disease, or atrial fibrillation at baseline

Comparison

Exercise-induced silent myocardial ischemia vs Men without silent myocardial ischemia during…

Design

Cohort

Follow-up

average 10 years

Authors

SKSudhir KurlPreventive Cardiology JLJari A. LaukkanenPreventive Cardiology TTTomi TuomainenUniversity of Eastern Finland

Discussion

Member takes

Implication

Silent ischemia on exercise testing was associated with higher CVD death and stroke risk; leaves open whether screening improves outcomes in asymptomatic men.

Key Points

This study aims to investigate the prognostic importance of silent myocardial ischemia during exercise regarding the risk of stroke and cardiovascular diseases in asymptomatic men.
Included 1726 middle-aged men with no history of stroke or coronary heart disease at baseline.
Silent myocardial ischemia was defined as ST-segment depression during exercise electrocardiography.
Average follow-up duration was 10 years.
Men with silent ischemia had a 3.5-fold increased risk of cardiovascular disease death.
A 2.2-fold increased risk of stroke was observed in men with silent ischemia.
Higher risks for CVD were also noted in smokers (3.8-fold), hypercholesterolemic subjects (3.9-fold), hypertensives (3.6-fold), and overweight men (3.8-fold).

Structured PICO

Does exercise-induced silent myocardial ischemia predict the risk of stroke and cardiovascular disease death in asymptomatic middle-aged men?

Population

1726 middle-aged men with no history of stroke, coronary heart disease, or atrial fibrillation at baseline

Intervention

Exercise-induced silent myocardial ischemia (defined as horizontal or downsloping ST-segment depression ≥1 mm during exercise electrocardiography)

Comparator

Men without silent myocardial ischemia during exercise

Outcome

Risk of stroke and cardiovascular disease (CVD) deathhard clinical

Exercise-induced silent myocardial ischemia is a strong independent predictor of stroke and cardiovascular death in asymptomatic middle-aged men, particularly those with conventional risk factors.

Cite This Study

Kurl et al. (2003) studied this question.

synapsesocial.com/papers/6a2124bcf9ede0d10bc3b32d https://doi.org/10.1161/01.str.0000078564.46376.0a

Topics

Hypertension management Women and heart disease

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Implication

Silent ischemia on exercise testing was associated with higher CVD death and stroke risk; leaves open whether screening improves outcomes in asymptomatic men.

Association of Exercise-Induced, Silent ST-Segment Depression With the Risk of Stroke and Cardiovascular Diseases in Men

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Association of Exercise-Induced, Silent ST-Segment Depression With the Risk of Stroke and Cardiovascular Diseases in Men

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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