Why the study?
Does the combination of losartan and hydrochlorothiazide reduce ambulatory systolic blood pressure more than hydrochlorothiazide monotherapy in patients with ambulatory systolic hypertension?
Population
120 patients with ambulatory systolic hypertension (n=60 per group)
Comparison
Losartan 50 mg for 6 weeks, force-titrated to… vs Hydrochlorothiazide 12.5 mg for 6 weeks…
Design
RCT, Randomized, Sham-titration used for the control group
Follow-up
18 weeks (three 6-week periods)
Authors
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Losartan-HCTZ combinations lower ambulatory BP more than HCTZ monotherapy or dose escalation; confirms fixed-dose ARB-diuretic benefit in systolic hypertension.
Does the combination of losartan and hydrochlorothiazide reduce ambulatory systolic blood pressure more than hydrochlorothiazide monotherapy in patients with ambulatory systolic hypertension?
Fixed-dose combinations of losartan and hydrochlorothiazide provide significantly greater reductions in ambulatory blood pressure than hydrochlorothiazide monotherapy in patients with systolic hypertension.
Yves Lacourcière (2003) studied this question.