Key result
Preoperative clopidogrel exposure significantly increased the risk of hemostatic reoperations (OR 5.1; 95% CI 2.47-10.47; P<0.01) and blood transfusions during and after off-pump CABG surgery.
Why the study?
Does preoperative clopidogrel administration increase bleeding complications and transfusion requirements in patients undergoing off-pump coronary artery bypass graft surgery?
Population
1,572 patients undergoing isolated off-pump coronary artery bypass graft surgery between January 2000 and…
Comparison
Preoperative clopidogrel administration vs No preoperative clopidogrel administration
Design
Cohort
Follow-up
operative/postoperative period
Authors
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Advises caution with preoperative clopidogrel before off-pump CABG; leaves open randomized confirmation of bleeding risks.
Cohort (n=1,572)
Does preoperative clopidogrel administration increase bleeding complications and transfusion requirements in patients undergoing off-pump coronary artery bypass graft surgery?
Odds Ratio: 5.1 (95% CI 2.47–10.47)
p-value: p=<0.01
Preoperative clopidogrel administration significantly increases the risk of bleeding complications and transfusion requirements in patients undergoing off-pump CABG without affecting operative mortality.
Kapetanakis et al. (2006) conducted a cohort in Isolated off-pump coronary artery bypass graft surgery (n=1,572). Clopidogrel premedication vs. No clopidogrel premedication was evaluated on Hemostatic reoperations (OR 5.1, 95% CI 2.47 to 10.47, p=<0.01). Preoperative clopidogrel exposure significantly increased the risk of hemostatic reoperations (OR 5.1; 95% CI 2.47-10.47; P<0.01) and blood transfusions during and after off-pump CABG surgery.
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