April 1, 1995Journal of Clinical InvestigationOpen Access

24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.

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Why the study?

Does oscillatory insulin infusion improve glucose utilization and reduce blood glucose levels compared to continuous insulin administration in normal young men?

Population

9 normal young men, non-obese, with normal fasting glucose and insulin levels, no history of endocrine or…

Comparison

Exogenous insulin infused in a sinusoidal… vs Exogenous insulin infused at a constant rate of…

Design

RCT, Each subject participated in two studies in randomized order

Follow-up

28 hours per session

Authors

JSJeppe SturisNovo Nordisk (Denmark)ASAndré ScheenUniversity of Liège RLRachel LeproultUniversité Libre de Bruxelles

Discussion

Member takes

Implication

Supports testing oscillatory insulin delivery clinically; extends evidence for ultradian rhythms in glucose homeostasis.

Structured PICO

Does oscillatory insulin infusion improve glucose utilization and reduce blood glucose levels compared to continuous insulin administration in normal young men?

Population

9 normal young men (ages 21.3 ± 0.7 yr), non-obese, with normal fasting glucose and insulin levels, no history of endocrine or psychiatric disorder, nonsmokers, not taking any drugs.

Intervention

Exogenous insulin infused in a sinusoidal oscillatory pattern (period of 120 min, amplitude 30% above and below the mean) at a mean rate of 0.3 mU/kg per min, alongside constant intravenous glucose (6 mg/kg per min) and somatostatin (140 µg/h) for 28 hours.

Comparator

Exogenous insulin infused at a constant rate of 0.3 mU/kg per min, alongside the same constant intravenous glucose and somatostatin infusions for 28 hours (randomized crossover design).

Outcome

Mean plasma glucose level over the 28-hour study period.surrogate

Ultradian oscillatory insulin infusion promotes more efficient glucose utilization and significantly lowers blood glucose levels compared to continuous infusion.

Cite This Study

Sturis et al. (1995) studied this question.

synapsesocial.com/papers/6a2143ce570f73dd9ac3debe https://doi.org/10.1172/jci117817

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24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider