Why the study?
Do spontaneous rapid oscillations in plasma insulin, glucagon, and glucose occur in humans, and do they differ between normal weight and obese individuals?
Population
20 humans, comprising 9 healthy normal weight subjects and 11 obese volunteers (145-316% ideal body weight).
Design
Cross-sectional
Follow-up
40-120 minutes
Authors
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Rapid insulin-glucose oscillations occur independently of obesity; hypothesis-generating for their role in metabolic regulation.
Do spontaneous rapid oscillations in plasma insulin, glucagon, and glucose occur in humans, and do they differ between normal weight and obese individuals?
Basal plasma levels of insulin, glucagon, and glucose fluctuate rapidly in humans with periods of 8-16 minutes, independent of obesity status.
Hansen et al. (1982) studied this question.
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