May 1, 1981Diabetes
Brief, Irregular Oscillations of Basal Plasma Insulin and Glucose Concentrations in Diabetic Man
Authors
Discussion
Loading...
Member takes
Implication
Physiological study reveals rapid synchronous insulin and glucose oscillations in maturity-onset diabetes, suggesting an intrinsic pancreatic pacemaker drives basal hormonal rhythms.
Key Points
- To determine whether basal plasma insulin and glucose concentrations exhibit rapid oscillatory patterns in patients with maturity-onset diabetes.
- Measured basal plasma insulin and glucose concentrations at 1-minute intervals for 2 hours in 12 diet-treated individuals with maturity-onset diabetes.
- Conducted time series analysis to identify cycle periodicity and assess synchrony between insulin pulses and glucose fluctuations.
- Detected brief, irregular insulin oscillations with a mean period of 8.8 minutes superimposed on longer fluctuations exceeding 30 minutes.
- Identified synchronous plasma glucose oscillations with a mean amplitude of 0.03 mmol/L coupled to short insulin cycles.
- Demonstrated that insulin oscillations occur independently of preceding glucose elevations, indicating an intrinsic pancreatic pacemaker that entrains glucose dynamics.
Cite This Study
Lang et al. (1981) studied this question.