Key result
Renin expression is heterogeneous throughout life, with renin-expressing cells spatially and temporally associated with the branching and development of the kidney vasculature in rats.
Population
Sprague Dawley rats during fetal (20 d) and postnatal (1 to 90 d) life
Design
Preclinical
Authors
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Hypothesis-generating for renin-mediated renal vascular development; leaves open translation to human congenital anomalies.
Renin-expressing cells are heterogeneously distributed during kidney development and are associated with the branching of renal arterioles, suggesting a role in renal vasculature development.
Reddi et al. (1998) studied Renal vascular development. Renin expression and distribution was evaluated on Renin distribution patterns along the renal arterial tree. Renin expression is heterogeneous throughout life, with renin-expressing cells spatially and temporally associated with the branching and development of the kidney vasculature in rats.
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