Key result
Genetic disruption of β1 and β2-adrenergic receptors significantly reduces basal renin expression along the developing preglomerular tree and in adult kidneys compared with wild-type mice.
Why the study?
Does genetic disruption of β1/β2-adrenergic receptors reduce renin expression in developing and adult kidneys in mice?
Does genetic disruption of β1/β2-adrenergic receptors reduce renin expression in developing and adult kidneys in mice?
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Genetic disruption of β-adrenergic receptors reduces basal renin expression along the developing preglomerular tree and in adult kidneys, indicating their critical role in early fetal development.
Neubauer et al. (2011) studied Renin expression during nephrogenesis. Targeted deletion of β1 and β2-adrenoceptors vs. Wild-type mice was evaluated on Renin expression at developmental stages. Genetic disruption of β1 and β2-adrenergic receptors significantly reduces basal renin expression along the developing preglomerular tree and in adult kidneys compared with wild-type mice.
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