Key result
Renin cell-specific deletion of G(s)alpha in mouse kidneys resulted in a near-complete absence of renin expression at all developmental stages and altered preglomerular arterial tree development.
Population
Mouse kidneys with renin cell-specific deletion of G(s)alpha
Design
Preclinical
Authors
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cAMP is required for patterned renin expression in developing kidney vasculature; leaves open its role in adult renovascular disease.
The cAMP signaling pathway, specifically G(s)alpha, is critical for establishing the juxtaglomerular expression site of renin during kidney development.
Neubauer et al. (2009) studied Kidney development. Renin cell-specific deletion of G(s)alpha vs. Normal G(s)alpha (implied) was evaluated on Spatiotemporal development of renin expression and preglomerular arterial tree. Renin cell-specific deletion of G(s)alpha in mouse kidneys resulted in a near-complete absence of renin expression at all developmental stages and altered preglomerular arterial tree development.
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