What question did this study set out to answer?

This research aims to determine how coronary artery disease affects the ventricular fibrillation threshold in patients during cardiac surgery.

October 1, 1979Circulation

The effects of coronary artery disease on the ventricular fibrillation threshold in man.

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Why the study?

Does coronary artery disease reduce the ventricular fibrillation threshold in humans?

Population

28 patients undergoing cardiac surgery, including 12 with ≥75% obstruction of the left anterior descending…

Comparison

Presence of severe coronary artery disease vs Absence of coronary artery disease

Design

Cross-sectional

Authors

LHLeonard N. HorowitzElectrophysiology JSJ F SpearNew York University Press MJM E JosephsonUniversity of California, Los Angeles

Discussion

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Implication

May indicate heightened arrhythmia susceptibility in CAD; hypothesis-generating and requires prospective confirmation before clinical application.

Key Points

This research aims to determine how coronary artery disease affects the ventricular fibrillation threshold in patients during cardiac surgery.
Ventricular fibrillation threshold measured in 28 patients during cardiac surgery.
100 Hz train of 24 rectangular pulses applied across ST segment and T wave.
Measurements taken from epicardial surface using a bipolar electrode probe.
Normal right ventricular fibrillation threshold was 24.3 ± 5.2 mA in six patients.
Normal left ventricular fibrillation threshold was 33.6 ± 5.4 mA in ten patients (p < 0.05).
In patients with ≥ 75% obstruction of the left anterior descending artery, left ventricular fibrillation threshold was 18.6 ± 6.9 mA, significantly lower than those without coronary artery disease (p < 0.001).

Structured PICO

Does coronary artery disease reduce the ventricular fibrillation threshold in humans?

Population

28 patients undergoing cardiac surgery, including 12 with ≥75% obstruction of the left anterior descending coronary artery and 16 without coronary artery disease.

Intervention

Presence of severe coronary artery disease (≥75% obstruction of the left anterior descending coronary artery)

Comparator

Absence of coronary artery disease

Outcome

Ventricular fibrillation threshold (VFT) measured in mAsurrogate

Coronary artery disease significantly reduces the ventricular fibrillation threshold in humans, potentially increasing susceptibility to arrhythmias.

Cite This Study

Horowitz et al. (1979) studied this question.

synapsesocial.com/papers/6a214930570f73dd9ac3e48e https://doi.org/10.1161/01.cir.60.4.792

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Implication

May indicate heightened arrhythmia susceptibility in CAD; hypothesis-generating and requires prospective confirmation before clinical application.

The effects of coronary artery disease on the ventricular fibrillation threshold in man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The effects of coronary artery disease on the ventricular fibrillation threshold in man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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