Key result
Lower LVEF shows no significant association with higher defibrillation thresholds.
Why the study?
Does defibrillation threshold increase as left ventricular ejection fraction decreases in patients receiving ICD/CRT-D?
Population
230 patients receiving ICD or CRT-D devices
Comparison
Defibrillation threshold testing with SVC coil… vs Comparison across different LVEF ranges
Design
Cohort
Authors
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May support standard DFT protocols across LVEF ranges; leaves open need for prospective validation.
Observational (n=230)
Yes
Does defibrillation threshold increase as left ventricular ejection fraction decreases in patients receiving ICD/CRT-D?
Absolute Event Rate: 425.8% vs 395.2%
p-value: p=not statistically significant
Defibrillation thresholds do not significantly increase as left ventricular ejection fraction decreases, suggesting standard DFT testing protocols remain applicable across a broad range of LVEF.
Val-Mejias et al. (2010) conducted an observational in Advanced cardiac disease requiring ICD/CRT-D (n=230). Decreased left ventricular ejection fraction (LVEF ≤ 25%) vs. Higher LVEF (LVEF ≥ 46%) was evaluated on Defibrillation threshold (DFT) estimates in Volts (p=not statistically significant). Decreasing left ventricular ejection fraction from ≥46% to ≤25% was associated with a minimal, non-significant increase in defibrillation threshold estimates (395.2 V vs 425.8 V).
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