Key result
Brain hemorrhage is linked to higher cardiac troponin I levels versus healthy controls.
Why the study?
Cardiac complications after stroke are a leading cause of death, but the relationship between changes in cardiac biomarkers and stroke required meta-analysis to explore the brain-heart axis.
Are cardiac biomarkers (cTn, BNP, NT-proBNP) significantly elevated in patients following different types of stroke?
Systematic Review (n=2,234)
Are cardiac biomarkers (cTn, BNP, NT-proBNP) significantly elevated in patients following different types of stroke?
Answers are grounded in this paper and cite their sources.
Cardiac biomarkers including cTnI, BNP, and NT-proBNP are significantly elevated following various types of stroke, highlighting the clinical importance of monitoring cardiac function due to the brain-heart axis.
BACKGROUND: Cardiac complications after a stroke are the second leading cause of death worldwide, affecting the treatment and outcomes of stroke patients. Cardiac biomarkers such as cardiac troponin (cTn), brain natriuretic peptide (BNP), and N-terminal pro-brain natriuretic peptide (NT-proBNP) have been frequently reported in patients undergoing a stroke. The aim of the present study is to meta-analyze the relationship between changes in such cardiac biomarkers and stroke and to present a systematic review of the previous literature, so as to explore the brain-heart axis. METHODS: We searched four online databases pertinent to the literature, including PubMed, Embase, the Cochrane Library, and the Web of Science. Then, we performed a meta-analysis to investigate changes in cTn, BNP, and NT-proBNP associated with different types of stroke. RESULTS AND CONCLUSIONS: A significant increase in cTnI concentration was found in patients exhibiting a brain hemorrhage. BNP increased in cases of brain infarction, while the NT-proBNP concentration was significantly elevated in patients suffering an acute ischemic stroke and brain hemorrhage, indicating cardiac damage and dysfunction after a stroke. Our analysis suggests that several potential mechanisms may be involved in the brain-heart axis. Finally, clinicians should pay careful attention to monitoring cardiac function in the treatment of cerebrovascular diseases in order to provide a timely and more accurate treatment.
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Xu et al. (2020) conducted a systematic review in Stroke (brain hemorrhage and acute ischemic stroke) (n=2,234). Brain hemorrhage vs. Healthy controls was evaluated on Cardiac troponin I (cTnI) concentration (WMD 1.57, 95% CI 0.61-2.54, p=0.001). Brain hemorrhage was associated with a significant increase in cardiac troponin I concentrations (WMD 1.57) compared to healthy controls, indicating myocardial damage after stroke.
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