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March 1, 1969Journal of Clinical InvestigationOpen Access

Hemodynamic effects of isoproterenol and norepinephrine in acute cardiac tamponade

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This research aims to evaluate the hemodynamic effects of isoproterenol and norepinephrine during cardiac tamponade.
Evaluated hemodynamic responses in eight anesthetized dogs under cardiac tamponade.
Administered isoproterenol infusion at 0.5 mug/kg per min and norepinephrine at various doses.
Monitored changes in pericardial pressure, right atrial pressure, cardiac output, and stroke volume.
Isoproterenol infusion increased cardiac output from 44.8 ml/kg per min to 105.6 ml/kg per min (P < 0.001).
Stroke volume improved from 6.1 ml to 12.1 ml with isoproterenol (P < 0.001).
Heart rate increased from 193.3 to 217.5 beats/min with isoproterenol (P < 0.05), while norepinephrine showed inconsistent effects.

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Implication

Randomized trial evaluates hemodynamic changes in dogs during cardiac tamponade with isoproterenol and norepinephrine, suggesting potential treatment strategies.

Cite This Study

Fowler et al. (1969) studied this question.

synapsesocial.com/papers/6a214e11baff55cd0402f45c https://doi.org/10.1172/jci106007

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Implication

Randomized trial evaluates hemodynamic changes in dogs during cardiac tamponade with isoproterenol and norepinephrine, suggesting potential treatment strategies.

Hemodynamic effects of isoproterenol and norepinephrine in acute cardiac tamponade

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Discussion

Implication

Cite This Study

Hemodynamic effects of isoproterenol and norepinephrine in acute cardiac tamponade

Key Points

Discussion

Implication

Cite This Study

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