November 16, 1999CirculationOpen Access

Progressive Loss of Myocardial ATP Due to a Loss of Total Purines During the Development of Heart Failure in Dogs

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Population

Dogs with cardiac dysfunction and heart failure induced by chronic right ventricular pacing

Design

Preclinical

Follow-up

7 to 9 weeks

Authors

WSWeiqun ShenBrigham and Women's Hospital KAKuniya AsaiHeart Failure & Transplant MUMasami UechiCardiac Surgery

Discussion

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Implication

Hypothesis-generating in canine HF; human studies needed before clinical translation.

Structured PICO

Population

Dogs with cardiac dysfunction and heart failure induced by chronic right ventricular pacing

Intervention

Chronic right ventricular pacing for 1 to 2 weeks, 3 to 4 weeks, and 7 to 9 weeks

Outcome

Myocardial ATP, total purine, and creatine levels measured in biopsy specimenssurrogate

In a canine model of pacing-induced heart failure, myocardial ATP progressively decreases due to a loss of the total purine pool, with creatine loss serving as an early marker.

Cite This Study

Shen et al. (1999) studied this question.

synapsesocial.com/papers/6a214f6ea2a97f3a085aefeb https://doi.org/10.1161/01.cir.100.20.2113

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Progressive Loss of Myocardial ATP Due to a Loss of Total Purines During the Development of Heart Failure in Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Progressive Loss of Myocardial ATP Due to a Loss of Total Purines During the Development of Heart Failure in Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider