Mitochondrial ATPase and high-energy phosphates in failing hearts
Why the study?
Does increased cardiac work state alter high-energy phosphates and mitochondrial ATPase protein expression in pig models of left ventricular remodeling and congestive heart failure?
Population
24 pigs
Comparison
Dobutamine-dopamine infusion and pacing to… vs Normal pigs and baseline state
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Impaired energetics during stress linked to ATPase loss in porcine HF; hypothesis-generating, no immediate clinical implications.
Structured PICO
Does increased cardiac work state alter high-energy phosphates and mitochondrial ATPase protein expression in pig models of left ventricular remodeling and congestive heart failure?
P
Population
24 pigs (17 after left circumflex coronary artery ligation resulting in compensated left ventricular remodeling [n=9] or congestive heart failure [n=8], and 7 normal pigs)
I
Intervention
Dobutamine-dopamine infusion and pacing (if needed) to increase cardiac work state
C
Comparator
Normal pigs and baseline state
O
Outcome
High-energy phosphates (PCr-to-ATP ratio, free ADP) measured via 31P magnetic resonance spectroscopy, and mitochondrial ATPase protein expressionsurrogate
In a porcine model of heart failure, reduced mitochondrial F(0)F(1)-ATPase protein expression is associated with impaired high-energy phosphate metabolism during increased cardiac work.
Cite This Study
Liu et al. (2001) studied this question.