Key result
In neonatal rat hearts, 5x10^-5M ouabain produced a 158.2% increase in dP/dt at 6.2 days of age compared with a 17.2% increase at 21.1 days (P<0.001).
Population
Neonatal rat hearts during the initial 21 days of life (specifically comparing age 6.2 days and 21.1 days)
Comparison
Ouabain, increased stimulation frequency, and… vs Responses at different ages and baseline perfusion
Design
Preclinical
Authors
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Highlights potential age-related differences in cardiac glycoside response; leaves open clinical translation from rodent models.
Absolute Event Rate: 158.2% vs 17.2%
p-value: p=<0.001
The study demonstrates that Na+ flux through a slow membrane channel plays a significant role in the positive staircase and glycoside responses of the early neonatal rat heart, which diminishes as the heart matures.
Langer et al. (1975) studied Neonatal rat heart physiology. Ouabain vs. 21.1 days of age was evaluated on Increase in dP/dt (p=<0.001). In neonatal rat hearts, 5x10^-5M ouabain produced a 158.2% increase in dP/dt at 6.2 days of age compared with a 17.2% increase at 21.1 days (P<0.001).
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