Why the study?
Does perindopril once daily improve left ventricular morphology and function compared to captopril twice daily in hypertensive patients?
Does perindopril once daily improve left ventricular morphology and function compared to captopril twice daily in hypertensive patients?
Perindopril once daily is as effective as captopril twice daily in lowering blood pressure and inducing regression of left ventricular hypertrophy in hypertensive patients.
Answers are grounded in this paper and cite their sources.
Supports once-daily perindopril as convenient alternative to twice-daily captopril; confirms comparable efficacy for BP control and LV mass regression.
Using digitized M-mode echocardiograms, we compared, in a double-blind study, the effects of 4 to 8 mg perindopril given once daily and 25 to 50 mg captopril given twice daily on the left ventricle (LV) in 20 hypertensive patients. Both treatments significantly (P less than .001) lowered blood pressure, reducing systemic vascular resistances. After 3 months both drugs induced a comparable percentage of reduction in LV mass, with an increase in the peak rate of LV relaxation and no changes in the peak rate of LV contraction. Our results demonstrate that perindopril once daily is an effective antihypertensive agent; it is also able, like captopril, to induce regression of LV hypertrophy, with improvement in diastolic performance and no deterioration in ventricular systolic function.
No takes yet. Share an insight, caveat, or question.
Grandi et al. (1991) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: