October 5, 2005Journal of Hypertension
Perindopril/indapamide combination more effective than enalapril in reducing blood pressure and left ventricular mass: the PICXEL study
Why the study?
Does first-line combination therapy with perindopril/indapamide reduce blood pressure and left ventricular mass more than enalapril monotherapy in hypertensive patients with LVH?
Population
556 hypertensive patients with left ventricular hypertrophy (LVH)
Comparison
First-line combination therapy with… vs Monotherapy with enalapril for 1 year
Design
RCT, randomized, double-blind, with central and blinded reading of…
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Supports initial perindopril/indapamide over enalapril for LVH regression in hypertension; extends evidence for first-line combination therapy.
Structured PICO
Does first-line combination therapy with perindopril/indapamide reduce blood pressure and left ventricular mass more than enalapril monotherapy in hypertensive patients with LVH?
P
Population
556 hypertensive patients with left ventricular hypertrophy (LVH)
I
Intervention
First-line combination therapy with perindopril/indapamide (increasing dosage) for 1 year
C
Comparator
Monotherapy with enalapril (increasing dosage) for 1 year
O
Outcome
Changes in blood pressure and echocardiographic measures of LVH (left ventricular mass index) from baseline to the end of treatment (1 year)surrogate
First-line combination therapy with perindopril/indapamide is more effective than enalapril monotherapy in reducing blood pressure and left ventricular mass in hypertensive patients with LVH.
Cite This Study
Dahlöf et al. (2005) studied this question.