Key result
In EMC-virus-infected cells, a correlation exists between membrane alterations and the inhibition of host protein synthesis, whereas this correlation was not apparent in poliovirus-infected cells.
Population
Mammalian cells (L cells, HeLa cells)
Design
Preclinical
Authors
Loading...
Supports virus-specific membrane roles in host shut-off; leaves open generalizability across picornaviruses and cell systems.
The kinetic pattern of host protein synthesis shut-off and permeability modification in picornavirus-infected cells is variable and depends on the cell line and multiplicity of infection.
Lacal et al. (1982) studied Picornavirus infection. Picornavirus infection (EMC virus and poliovirus) vs. Uninfected cells was evaluated on Inhibition of host protein synthesis and modification of membrane permeability. In EMC-virus-infected cells, a correlation exists between membrane alterations and the inhibition of host protein synthesis, whereas this correlation was not apparent in poliovirus-infected cells.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: