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February 1, 1981Journal of VirologyOpen Access

Reversion by hypotonic medium of the shutoff of protein synthesis induced by encephalomyocarditis virus

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Why the study?

Does hypotonic medium treatment reverse the inhibition of host protein synthesis in encephalomyocarditis virus-infected HeLa cells?

Population

Human HeLa cells infected by encephalomyocarditis virus

Comparison

Hypotonic medium treatment vs Normal or hypertonic medium

Design

Preclinical

Authors

MAMiguel A. AlonsoIntegrated BioTherapeutics (United States)LCLuis CarrascoThe Honourable Society of Lincoln's Inn

Discussion

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Implication

No immediate clinical application; leaves open ion modulation as a research target for selective antiviral translation control.

Structured PICO

Does hypotonic medium treatment reverse the inhibition of host protein synthesis in encephalomyocarditis virus-infected HeLa cells?

P
Population
Human HeLa cells infected by encephalomyocarditis virus
I
Intervention
Hypotonic medium treatment
C
Comparator
Normal or hypertonic medium (or high concentration of NaCl/KCl)
O
Outcome
Viral and cellular protein synthesis (translation of mRNA)surrogate

The study demonstrates that monovalent ion concentration regulates the discrimination between viral and cellular mRNA translation in virus-infected animal cells.

Cite This Study

Alonso et al. (1981) studied this question.

synapsesocial.com/papers/6a8bbc256fd527af12e3aa5ehttps://doi.org/10.1128/jvi.37.2.535-540.1981
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of translation by poliovirus: inactivation of a specific initiation factor.1978 · 200 citations
  2. 2Poliovirus-induced inhibition of polypeptide initiation in vitro on native polyribosomes.1976 · 69 citations
  3. 3Alterations in initiation factor activity from poliovirus-infected HeLa cells.1979 · 59 citations
  4. 4Control of protein synthesis in extracts from poliovirus-infected cells. I. mRNA discrimination by crude initiation factors1978 · 87 citations
  5. 5Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells.1980 · 163 citations