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This research aims to investigate the effects of translation inhibitors on virus-infected mammalian cells, focusing on permeability changes.

January 1, 1979Journal of VirologyOpen Access

Selective inhibition of protein synthesis in virus-infected mammalian cells

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Randomized trial tests translation inhibitors on virus-infected cells, suggesting permeability changes enhance drug uptake.

This research aims to investigate the effects of translation inhibitors on virus-infected mammalian cells, focusing on permeability changes.
Tested different translation inhibitors on control and encephalomyocarditis virus-infected mouse 3T6 cells.
Assessed the uptake and efficacy of gougerotin, edeine, and blasticidin S in infected versus uninfected cells.
Analyzed permeabilities in various virus-infected cell types, including mengovirus and Semliki Forest virus.
Gougerotin, edeine, and blasticidin S specifically inhibited protein synthesis in virus-infected cells but not in uninfected cells.
Membrane permeability changes allowed drug uptake when viral protein synthesis began.
Zinc ions prevented gougerotin from inhibiting protein synthesis by blocking entry into the infected cells.

Contreras et al. (1979) studied this question.

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