Key result
Mengovirus infection of mouse L cells induces a ribosome-bound inhibitor that halts translation after 80S initiation complex formation but before elongation.
Mengovirus infection in mouse L cells induces a ribosome-bound inhibitor that halts translation after initiation complex formation.
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Hypothesis-generating for antiviral strategies targeting translation; leaves open relevance to human cells and infections.
Pensiero et al. (1985) studied Mengovirus infection. Mengovirus infection vs. Mock-infected cells was evaluated on Protein synthesis inhibition and ribosome activity. Mengovirus infection of mouse L cells induces a ribosome-bound inhibitor that halts translation after 80S initiation complex formation but before elongation.
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