Key result
Vesicular stomatitis virus infection of mouse L cells inhibits translation initiation due to a defective ribosome-associated factor present in the 0-40% ammonium sulfate fraction.
Population
Mouse L cells infected with vesicular stomatitis virus (VSV) for 4 hours
Comparison
Vesicular stomatitis virus (VSV) infection vs Mock-infected cells
Design
Preclinical
Authors
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Does not inform human viral therapies; leaves open whether defective eIF-3/4B factors drive translation shutoff in other systems.
Infection of mouse L cells with vesicular stomatitis virus inhibits protein synthesis at the initiation stage by altering specific ribosome-associated initiation factors.
Thomas et al. (1983) studied Vesicular stomatitis virus infection. Vesicular stomatitis virus infection vs. Mock-infected cells was evaluated on Inhibition of translation / protein synthesis. Vesicular stomatitis virus infection of mouse L cells inhibits translation initiation due to a defective ribosome-associated factor present in the 0-40% ammonium sulfate fraction.
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