Key result
Poly I:C inhibits in vitro mengovirus RNA translation by ~75% in interferon-treated L-cell lysates.
Poly I:C strongly inhibits mengovirus RNA translation in interferon-treated cell lysates without altering the ribosomal initiation sites.
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Caution against extrapolating L-cell findings to human antiviral therapy; leaves open interferon effects on viral translation in vivo.
Degener et al. (1983) studied this question. poly I:C vs. untreated controls was evaluated on in vitro translation of mengovirus RNA. The addition of 40 ng/ml of poly I:C to lysates of interferon-treated L-cells resulted in a 70 to 75% inhibition of the in vitro translation of mengovirus RNA.
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