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June 1, 1966Journal of BacteriologyOpen Access

Replication of Mengovirus I. Effect on Synthesis of Macromolecules by Host Cell

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Population

Two strains of Novikoff (rat) hepatoma cells (N1S1-63 and N1S1-67) propagated in vitro

Design

Preclinical

Authors

PPPeter G.W. PlagemannFraunhofer Institute for Manufacturing Technology and Advanced MaterialsHSH. E. SwimUniversity of Utah

Discussion

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Overview

May guide viral host-shutoff models; leaves open in vivo or clinical translation.

Structured PICO

P
Population
Two strains of Novikoff (rat) hepatoma cells (N1S1-63 and N1S1-67) propagated in vitro
I
Intervention
Mengovirus infection
O
Outcome
Effect on synthesis of macromolecules (RNA and protein synthesis) and viral replication cyclesurrogate

Mengovirus infection depresses host macromolecule synthesis in a strain-specific manner in Novikoff hepatoma cells.

Cite This Study

Plagemann et al. (1966) studied this question.

synapsesocial.com/papers/6a89514540fe6a3effcaffaehttps://doi.org/10.1128/jb.91.6.2317-2326.1966
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A New Ribonucleic Acid Polymerase Appearing after Mengovirus Infection of L-Cells1963 · 124 citations
  2. 2High-Resolution Density Gradient Sedimentation Analysis1960 · 790 citations
  3. 3INDUCTION BY AN RNA PHAGE OF AN ENZYME CATALYZING INCORPORATION OF RIBONUCLEOTIDES INTO RIBONUCLEIC ACID1963 · 94 citations