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May 1, 1968Journal of VirologyOpen Access

Mengovirus Replication in Novikoff Rat Hepatoma and Mouse L Cells: Effects on Synthesis of Host-Cell Macromolecules and Virus-specific Synthesis of Ribonucleic Acid

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Population

Novikoff cells (strain N1S1-67) and L-67 cells (a nutritional mutant of mouse L cells)

Comparison

Mengovirus infection vs Uninfected cells and comparison between the two…

Design

Preclinical

Authors

PPPeter G.W. PlagemannFraunhofer Institute for Manufacturing Technology and Advanced Materials

Discussion

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Overview

Cell-type differences in actinomycin D sensitivity leave open host-factor roles in mengovirus replication; mechanistic studies needed before generalization.

Structured PICO

P
Population
Novikoff cells (strain N1S1-67) and L-67 cells (a nutritional mutant of mouse L cells)
I
Intervention
Mengovirus infection
C
Comparator
Uninfected cells and comparison between the two cell lines
O
Outcome
Synthesis of host-cell RNA and protein, viral RNA synthesis, and viral RNA polymerase activitysurrogate

Mengovirus replication dynamics are similar in Novikoff rat hepatoma and mouse L cells, though they differ in their sensitivity to actinomycin D prior to infection.

Cite This Study

Peter G.W. Plagemann (1968) studied this question.

synapsesocial.com/papers/6a8a779e1e528df4f2ec73c6https://doi.org/10.1128/jvi.2.5.461-473.1968
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Replication of Mengovirus I. Effect on Synthesis of Macromolecules by Host Cell1966 · 122 citations
  2. 2A New Ribonucleic Acid Polymerase Appearing after Mengovirus Infection of L-Cells1963 · 124 citations
  3. 3A COMPARISON OF THE CHANGES IN FINE STRUCTURE OF L CELLS DURING SINGLE CYCLES OF VIRAL MULTIPLICATION, FOLLOWING THEIR INFECTION WITH THE VIRUSES OF MENGO AND ENCEPHALOMYOCARDITIS1962 · 94 citations
  4. 4Hydrolytic Enzymes in KB Cells Infected with Poliovirus and Herpes Simplex Virus1966 · 72 citations
  5. 5High-Resolution Density Gradient Sedimentation Analysis1960 · 790 citations