Why the study?
Do translation-blocking antibiotics selectively inhibit protein synthesis and reduce virus yield in virus-infected cells?
Population
Intact mouse L and 3T6 cells, and hamster BHK 21 cells, both uninfected and infected with…
Comparison
Antibiotics known to block translation in… vs Uninfected cells or untreated virus-infected cells
Design
Preclinical
Authors
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Hypothesis-generating for selective antiviral activity of membrane-impermeant antibiotics; leaves open translation to human efficacy and safety.
Do translation-blocking antibiotics selectively inhibit protein synthesis and reduce virus yield in virus-infected cells?
Translation-blocking antibiotics that are impermeable to normal cells can selectively enter virus-infected cells and inhibit viral replication, suggesting a potential strategy for antiviral agents.
Lacal et al. (1980) studied this question.
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