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July 1, 1982Journal of General Virology

Protein Synthesis in HeLa Cells Double-infected with Encephalomyocarditis Virus and Poliovirus

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Population

HeLa cells

Comparison

Double-infection with encephalomyocarditis virus… vs Single virus infection or different…

Design

Preclinical

Authors

MAMiguel A. AlonsoIntegrated BioTherapeutics (United States)LCLuis CarrascoThe Honourable Society of Lincoln's Inn

Discussion

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Implication

Viral interference patterns warrant cautious interpretation in mixed infections; leaves open translation competition mechanisms for in vivo validation.

Structured PICO

P
Population
HeLa cells
I
Intervention
Double-infection with encephalomyocarditis (EMC) virus and poliovirus under various conditions (co-infection, superinfection, guanidine treatment, varying ionic media)
C
Comparator
Single virus infection or different timing/multiplicities of infection
O
Outcome
Pattern of host and viral protein synthesissurrogate

The study demonstrates complex interactions and competition for translation machinery between EMC virus and poliovirus in double-infected HeLa cells.

Cite This Study

Alonso et al. (1982) studied this question.

synapsesocial.com/papers/6a83f8a847147a06038de2cehttps://doi.org/10.1099/0022-1317-61-1-15
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Encephalomyocarditis Viral RNA Can Be Translated Under Conditions of Poliovirus-Induced Translation Shutoff In Vivo1981 · 9 citations
  2. 2Reversion by hypotonic medium of the shutoff of protein synthesis induced by encephalomyocarditis virus1981 · 45 citations
  3. 3Protein Synthesis and Membrane Integrity in Interferon-treated HeLa Cells Infected with Encephalomyocarditis Virus1981 · 28 citations
  4. 4Inhibition of translation by poliovirus: inactivation of a specific initiation factor.1978 · 200 citations
  5. 5Alterations in initiation factor activity from poliovirus-infected HeLa cells.1979 · 59 citations