Key result
By 24 hours post-injection of 35S-sulfate, the relative specific radioactivity of the most dense rabbit platelet subpopulation was 7 times greater than that of the least dense subpopulation.
Population
Rabbit platelets from anticoagulated rabbit blood
Design
Preclinical
Follow-up
5 days
Authors
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No clinical implications for humans; leaves open whether density loss drives platelet clearance.
Young rabbit platelets are denser and decrease in density as they age in circulation, potentially leading to clearance due to loss of surface sialic acid.
Rand et al. (1981) studied this question. 35S-sulfate intravenous injection vs. Comparison between most dense and least dense platelet subpopulations was evaluated on Relative specific radioactivity of platelet density subpopulations. By 24 hours post-injection of 35S-sulfate, the relative specific radioactivity of the most dense rabbit platelet subpopulation was 7 times greater than that of the least dense subpopulation.
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