Why the study?
Can arabinogalactan density-gradient centrifugation separate thrombin-treated platelets from normal platelets?
Population
Washed rabbit platelets (normal and thrombin-treated) and in vivo rabbit model
Comparison
Arabinogalactan density-gradient centrifugation vs Normal washed rabbit platelets
Design
Preclinical
Authors
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May enable isolation of thrombin-exposed platelets in models; leaves open clinical detection of in vivo thrombosis.
Can arabinogalactan density-gradient centrifugation separate thrombin-treated platelets from normal platelets?
Density-gradient centrifugation effectively separates thrombin-treated platelets into less dense fractions, offering a potential method to detect platelets exposed to thrombin during in vivo thrombus formation.
Cieslar et al. (1979) studied this question.
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