What question did this study set out to answer?

This research investigates how low concentrations of thrombin affect rabbit platelet function, metabolism, and survival over repeated exposures.

November 1, 1973British Journal of Haematology

Effect of Repeated Treatment of Rabbit Platelets with Low Concentrations of Thrombin on their Function, Metabolism and Survival

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Authors

HRH. J. ReimersKlinik Bad Oexen MPMarian A. PackhamUniversity of Toronto RKR L Kinlough-RathboneYork University

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Implication

Randomized trial examines how repeated thrombin treatment affects rabbit platelet function and metabolism, suggesting important insights into platelet behavior.

Key Points

This research investigates how low concentrations of thrombin affect rabbit platelet function, metabolism, and survival over repeated exposures.
Washed rabbit platelets treated with low concentrations of thrombin for multiple aggregations.
Labeling of platelets with [3H]serotonin and [32P] orthophosphate to measure serotonin and nucleotide release.
Assessment of platelet aggregation responses to ADP and high concentrations of thrombin.
Approximately 70% of [3H]serotonin and 60-65% of labeled nucleotides were released after three thrombin treatments.
Thrombin-treated platelets demonstrated enhanced sensitivity to ADP-induced aggregation.
Thrombin treatment did not affect the survival time of treated platelets in vivo when compared to controls.

Cite This Study

Reimers et al. (1973) studied this question.

synapsesocial.com/papers/6a215915baff55cd040300f9 https://doi.org/10.1111/j.1365-2141.1973.tb01780.x

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Implication

Randomized trial examines how repeated thrombin treatment affects rabbit platelet function and metabolism, suggesting important insights into platelet behavior.

Effect of Repeated Treatment of Rabbit Platelets with Low Concentrations of Thrombin on their Function, Metabolism and Survival

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of Repeated Treatment of Rabbit Platelets with Low Concentrations of Thrombin on their Function, Metabolism and Survival

Discussion

Member takes

Implication

Key Points

Cite This Study

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