Key result
Human platelets that have undergone the release reaction are not readily deaggregated by EDTA or PGE1, suggesting a third type of platelet-platelet adherence not disrupted by EDTA.
The study identifies species differences in platelet deaggregation, suggesting a calcium-independent mechanism of platelet-platelet adherence in human platelets following the release reaction.
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Highlights potential calcium-independent platelet adherence in humans; leaves open its clinical relevance to thrombosis and antiplatelet strategies.
Kinlough-Rathbone et al. (1983) studied this question. EDTA, PGI2, or PGE1 was evaluated on Platelet deaggregation and 125I-fibrinogen dissociation. Human platelets that have undergone the release reaction are not readily deaggregated by EDTA or PGE1, suggesting a third type of platelet-platelet adherence not disrupted by EDTA.
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