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This article reviews the molecular determinants, electrophysiological diversity, and functional consequences of in vivo alterations in voltage-gated myocardial K+ channels.
This review outlines the molecular diversity, genetics, and functional roles of voltage-gated potassium channels in the mammalian heart, including their implications for arrhythmias and QT prolongation.
The sections in this article are: Electrophysiological Diversity of Voltage‐Gated Myocardial K + Channel Currents Transient Outward K + Current Channels, I to Delayed Rectifier K + Currents, I K Cellular/Regional Heterogeneity in Voltage‐Gated K + Current Expression and Properties Molecular Determinants of Voltage‐Gated Cardiac K + Channels Voltage‐Gated K + Channel Pore‐Forming α Subunits Accessory Subunits of Voltage‐Gated K + Channels Voltage‐Gated K + Channels and the Cytoskeleton Molecular Correlates of Functional Voltage‐Gated K + Channels Molecular Genetics of Cardiac Delayed Rectifier K + Currents, I Kr and I Ks Transgenic and Targeted Gene Deletion Approaches Molecular Correlates of Other Voltage‐Gated Cardiac K + Currents Functional Consequences of in Vivo Alterations in Voltage‐Gated Myocardial K + Channels QT Prolongation Atrioventricular Block Ventricular Arrhythmia/Tachycardia Pathophysiology Summary, Conclusions, and Future Directions
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Jeanne M. Nerbonne (2002) conducted a review in Voltage-Gated K+ Channel Diversity and Functioning in the Mammalian Heart. This article reviews the molecular determinants, electrophysiological diversity, and functional consequences of in vivo alterations in voltage-gated myocardial K+ channels.
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