Key result
In rats with ischemic heart failure, 8 weeks of hydrochlorothiazide treatment improved ejection fraction (49.4% vs 40.1% in control) and reduced cardiac interstitial fibrosis.
Why the study?
Does hydrochlorothiazide improve cardiac function and reduce fibrosis in a rat model of ischemic heart failure?
Population
Adult male Sprague Dawley rats with ischemic heart failure induced by left anterior descending coronary…
Comparison
Hydrochlorothiazide 12.5 mg/kg/d for 8 weeks vs Control group, valsartan 80 mg/kg/d, furosemide…
Design
Preclinical, randomly divided into five groups
Follow-up
8 weeks
Authors
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Should not alter diuretic use in heart failure; leaves open translation of remodeling benefits from this rat model.
RCT (n=70)
Randomly divided
Does hydrochlorothiazide improve cardiac function and reduce fibrosis in a rat model of ischemic heart failure?
Absolute Event Rate: 49.4% vs 40.1%
In a rat model of ischemic heart failure, hydrochlorothiazide improved cardiac function and reduced remodeling, effects not seen with furosemide, potentially by inhibiting the angiotensin II signaling pathway.
Luo et al. (2016) conducted an RCT in Ischemic heart failure (n=70). Hydrochlorothiazide vs. Control group was evaluated on Ejection fraction. In rats with ischemic heart failure, 8 weeks of hydrochlorothiazide treatment improved ejection fraction (49.4% vs 40.1% in control) and reduced cardiac interstitial fibrosis.
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