Key result
Chlorothiazide therapy did not prevent or reverse cardiac hypertrophy or affect the 2-fold higher plasma atrial natriuretic peptide levels in rats with chronic myocardial infarction.
Why the study?
Does chlorothiazide reduce cardiac hypertrophy and alter vasoactive hormones in rats with chronic myocardial infarction?
Population
Rats with chronic myocardial infarction induced by left coronary artery ligation, and sham-operated controls.
Comparison
Chlorothiazide in drinking water for 4 weeks… vs Drinking water alone.
Design
Preclinical
Follow-up
4 weeks
Authors
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Does not support chlorothiazide for post-MI hypertrophy prevention; leaves open thiazide effects on remodeling in clinical HF.
Does chlorothiazide reduce cardiac hypertrophy and alter vasoactive hormones in rats with chronic myocardial infarction?
In a rat model of heart failure, chronic chlorothiazide therapy failed to reduce ventricular hypertrophy or extracellular sodium, likely due to compensatory activation of the renin-angiotensin system.
Kohzuki et al. (1996) studied chronic myocardial infarction. chlorothiazide vs. drinking water alone was evaluated on cardiac hypertrophy, circulating vasoactive hormones and exchangeable body sodium. Chlorothiazide therapy did not prevent or reverse cardiac hypertrophy or affect the 2-fold higher plasma atrial natriuretic peptide levels in rats with chronic myocardial infarction.
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