Key result
In hypertensive rats, low-dose combination of perindopril and candesartan decreased left ventricular weight and atrial natriuretic factor mRNA more potently than amlodipine alone or in combination.
Why the study?
Does combination therapy with perindopril and candesartan improve cardiovascular parameters more than monotherapy or combination with amlodipine in stroke-prone spontaneously hypertensive rats?
Population
Stroke-prone spontaneously hypertensive rats (SHRSP)
Comparison
Perindopril, candesartan cilexetil, or… vs Monotherapy with perindopril, candesartan, or…
Design
Preclinical
Follow-up
4 weeks
Authors
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Hypothesis-generating for ACEI/ARB synergy on hypertensive remodeling; human trials needed before clinical consideration.
Does combination therapy with perindopril and candesartan improve cardiovascular parameters more than monotherapy or combination with amlodipine in stroke-prone spontaneously hypertensive rats?
In a hypertensive rat model, combining an ACE inhibitor and an AT1 receptor antagonist was more effective at improving cardiac and vascular parameters than monotherapy or combination with a calcium channel blocker.
Kim et al. (2000) studied Hypertension. Combination of perindopril and candesartan cilexetil vs. Amlodipine alone or amlodipine combined with perindopril or candesartan was evaluated on Left ventricular weight and mRNA levels for atrial natriuretic factor. In hypertensive rats, low-dose combination of perindopril and candesartan decreased left ventricular weight and atrial natriuretic factor mRNA more potently than amlodipine alone or in combination.
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