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July 1, 1998Cardiovascular Research492 citations

Rat models of hypertension, cardiac hypertrophy and failure

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Population

Rat models of hypertension, cardiac hypertrophy, and heart failure

Design

Review

Key result

This review discusses the advantages and disadvantages of commonly used and recently introduced rat models for studying hypertension, cardiac hypertrophy, and heart failure.

Authors

SDSheila A Doggrell

Discussion

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Overview

May guide rat model selection for hypertension and HF research; leaves open optimal translational validity to humans.

Structured PICO

P
Population
Rat models of hypertension, cardiac hypertrophy, and heart failure

This review provides a comprehensive overview of the advantages and limitations of various rat models used in cardiovascular research for hypertension and heart failure.

Limitations

  • Ethical concerns and legislation regarding animal use
  • Insufficient mimicry of human disease in some models, such as acute onset of symptoms and lack of atherosclerosis

Cite This Study

Sheila A Doggrell (1998) conducted a review in Hypertension, cardiac hypertrophy, and heart failure. Rat models was evaluated. This review discusses the advantages and disadvantages of commonly used and recently introduced rat models for studying hypertension, cardiac hypertrophy, and heart failure.

synapsesocial.com/papers/6a216039baff55cd04030a46https://doi.org/10.1016/s0008-6363(98)00076-5
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