Key result
Among individuals with prediabetes, metabolic syndrome was independently associated with a higher risk of carotid plaques (OR 2.55; 95% CI 1.06-6.15; P=0.037) and increased carotid intima-media thickness.
Why the study?
Few studies have examined differences in cardiovascular risk according to the presence or absence of metabolic syndrome in individuals with prediabetes.
Does the presence of metabolic syndrome increase carotid atherosclerosis in individuals with prediabetes?
Cross-Sectional (n=328)
No
Does the presence of metabolic syndrome increase carotid atherosclerosis in individuals with prediabetes?
Odds Ratio: 2.55 (95% CI 1.06–6.15)
p-value: p=0.037
Metabolic syndrome is independently associated with increased carotid intima-media thickness and carotid plaques in individuals with prediabetes, indicating a higher risk of cardiovascular disease.
May flag higher subclinical CVD risk among prediabetes patients; leaves open whether metabolic syndrome modification alters carotid atherosclerosis progression.
Background: While the number of individuals with prediabetes and metabolic syndrome (MetS) is increasing, only a few studies have reported differences in cardiovascular risk according to the presence or absence of MetS in individuals with prediabetes. Here, we examined differences in carotid intima-media thickness (CIMT) and carotid plaques in individuals with prediabetes with or without MetS among subjects who visited a single center in Seoul (Huh Diabetes Center). Methods: A total of 328 participants aged ≥20 years, including the group with normoglycemia, were enrolled in the analysis, of which 273 had prediabetes. Individuals with prediabetes were defined as those who met one or more of the following two criteria: fasting plasma glucose of 100–125 mg/dL and/or HbA1c level of 5.7%–6.4%. Carotid atherosclerosis was determined by mean and maximal CIMT and by the presence of carotid plaques. Results: Eighty-nine subjects (32.6% of prediabetes group) were categorized as having MetS. Those with MetS had significantly higher mean CIMT and maximal CIMT than those without (P < 0.05). Moreover, the group with MetS had a significantly higher prevalence of carotid plaques than the group without MetS [odds ratio (OR): 2.45, 95% confidence interval (CI): 1.43–4.19; P = 0.001]. After adjusting for age, sex, body mass index, and low-density lipoprotein cholesterol, individuals with MetS still had greater mean and maximal CIMT than individuals without MetS (P < 0.05), and the presence of MetS was significantly associated with a higher risk of carotid plaques (OR: 2.55, 95% CI: 1.06–6.15; P = 0.037). Conclusion: These results suggest that MetS is independently associated with increased CIMT and the presence of carotid plaques in prediabetes. Our study indicates that the risk of cardiovascular disease (CVD) is high in prediabetic individuals with MetS, and that more attention is needed on the risk of CVD in these individuals.
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Jang et al. (2022) conducted a cross-sectional in Prediabetes and Metabolic Syndrome (n=328). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Presence of carotid plaques (OR 2.55, 95% CI 1.06-6.15, p=0.037). Among individuals with prediabetes, metabolic syndrome was independently associated with a higher risk of carotid plaques (OR 2.55; 95% CI 1.06-6.15; P=0.037) and increased carotid intima-media thickness.
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