Key result
Foot-and-mouth disease virus utilizes multiple integrin proteins and heparan sulfate as receptors to mediate host cell infection, which determines viral tropism and pathogenesis.
This review elucidates the molecular mechanisms of FMDV receptor utilization, providing a theoretical foundation for developing targeted antiviral strategies.
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May guide receptor-targeted FMDV antivirals in livestock; extends molecular insights but leaves open in vivo validation.
This study reviews the FMDV receptor-binding domain, integrin receptors, and heparan sulfate receptors to provide references for studies regarding the mechanisms underlying FMDV infection.
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Wang et al. (2015) conducted a review in Foot-and-mouth disease. FMDV receptors was evaluated. Foot-and-mouth disease virus utilizes multiple integrin proteins and heparan sulfate as receptors to mediate host cell infection, which determines viral tropism and pathogenesis.
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