Key result
Peripheral blood flow measured by the newly developed finger-occlusion plethysmograph strongly correlated with measurements from a standard laser Doppler flowmeter (r=0.79, p<0.001).
Why the study?
Does a new finger-occlusion plethysmograph accurately measure peripheral blood flow compared to a laser Doppler flowmeter in young volunteers?
Cross-Sectional (n=101)
No
Does a new finger-occlusion plethysmograph accurately measure peripheral blood flow compared to a laser Doppler flowmeter in young volunteers?
Effect estimate: r=0.79
p-value: p=<0.001
A newly developed finger-occlusion plethysmograph accurately estimates peripheral blood flow and allows calculation of peripheral vascular resistance, which may serve as a predictor of hypertension.
BACKGROUND: The aim of the present study was to measure peripheral blood flow (BF) with a new finger-occlusion plethysmograph (FOP) and to compare this to BF measured with a laser Doppler flowmeter (LDF). An additional objective was to investigate the relationship between hypertension-related clinical parameters and peripheral vascular resistance (PVR) estimated from BF and mean blood pressure (BP) (PVR=mean BP/BF) in young subjects. METHODS AND RESULTS: The present study employed 101 young volunteers (61 males, 40 females, mean age 23.2+/-2.5 years). The FOP was attached to the third finger and an LDF to the fourth fingertip of each subject. BF was measured simultaneously by the 2 devices. A multi-biomedical recorder (TM2425) measured 24-h BP. A high correlation was observed between BF measured by the FOP and LDF (r=0.79, p<0.001). In multiple linear regression analysis, PVR was independently correlated with a family history of hypertension (p<0.01) and with base diastolic BP during sleep (p<0.01), which is a sensitive predictor of severity of hypertension. CONCLUSIONS: Our newly developed FOP can estimate peripheral absolute BF easily. Furthermore, BF determined by the FOP can be used to calculate PVR, and an elevated PVR may be a useful predictor of hypertension.
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Kura et al. (2008) conducted a cross-sectional in Healthy volunteers (n=101). Finger-occlusion plethysmograph (FOP) vs. Laser Doppler flowmeter (LDF) was evaluated on Correlation of peripheral blood flow measurements between FOP and LDF (r=0.79, p=<0.001). Peripheral blood flow measured by the newly developed finger-occlusion plethysmograph strongly correlated with measurements from a standard laser Doppler flowmeter (r=0.79, p<0.001).
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