This review summarizes the physiological and genetic links between type 2 diabetes, obesity, and insulin resistance.
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Supports hypothesis generation on genetic links in obesity-related insulin resistance; does not alter current clinical management.
The article reviews the relationship between type 2 diabetes and obesity. This also includes types of obesity and its genetic predisposition. The modern generalization of sedentary life and caloric abundance has created new physiological conditions capable of changing the level of expression of a number of genes involved in fuel metabolism and body weight regulation. It is likely that the genetic variants or alleles of these genes have in the past participated in the adaptation of human physiology to its evolutionary constraints. In this article, we underscore the importance of obesity in relation to disorders of diverse etiologies characterized by disturbances of free fatty acids, visceral adiposity and insulin resistance. Further, we have investigated the role of selecting the traits to be subjected to quantitative genetic analysis in the occurrence of obesity
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Hussain et al. (2010) studied this question.
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