Why the study?
Does a modified PCR technique detect persistent enterovirus infection in culture-negative meningoencephalitis?
Population
A patient with antibody deficiency and chronic culture-negative meningoencephalitis
Comparison
Modified polymerase chain reaction technique vs Routine viral cultures and routine nucleic acid…
Design
Case_report
Authors
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May support modified PCR testing in culture-negative meningoencephalitis; leaves open need for prospective validation before clinical adoption.
Does a modified PCR technique detect persistent enterovirus infection in culture-negative meningoencephalitis?
This study provides the first definitive evidence for the persistence of enterovirus infection with negative viral cultures using modified PCR.
Rotbart et al. (1990) studied this question.
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