Key result
Nonpharmacological techniques for VT/VF resulted in low sudden death rates (3-6%), but VT/VF recurrences were more frequent after catheter ablation (57%) than map-guided surgery (18%, P<0.01).
Why the study?
Do nonpharmacological therapies (catheter ablation, surgery, ICD) prevent sudden death and recurrences in patients with ventricular tachycardia or fibrillation?
Cohort (n=554)
No
Do nonpharmacological therapies (catheter ablation, surgery, ICD) prevent sudden death and recurrences in patients with ventricular tachycardia or fibrillation?
Absolute Event Rate: 57% vs 18%
p-value: p=< 0.01
Nonpharmacological therapies for VT/VF are associated with low rates of sudden death, though catheter ablation has a higher rate of arrhythmia recurrence compared to map-guided surgery.
Low sudden death rates support nonpharmacological VT/VF use; leaves open ablation vs surgery preference in this cohort.
It has been shown that conventional antiarrhythmic drug treatment is debatable, and there is growing interest in nonpharmacological techniques. We studied the outcome of 554 patients with ventricular tachycardia (VT) or ventricular fibrillation (VF) who underwent nonpharmacological techniques from March 1980 to June 1994 at our institution. Catheter ablation was performed in 51 patients (G1), map guided surgery in 147 (G2), and cardioverter defibrillator implantation (ICD) in 356 (G3). During a mean follow-up of 37 +/- 12 (< 1-137) months, incidence of sudden death (G1 4%, G2 6%, G3 3%) and cardiac death (G1 7%, G2 16%, G3 8%) were relatively low, and there was no significant differences between G1-G3. VT/VF recurrences occurred more frequently in G1 (57%) than in G2 (18%) (P < 0.01). ICD discharges occurred in 69% of patients. We conclude that nonpharmacological techniques lead to low sudden death rates; however, there is a high rate of recurrence in G1. Risk stratification is necessary to select the ideal therapy for each individual patient.
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TRAPPE et al. (1994) conducted a cohort in Ventricular tachycardia or ventricular fibrillation (n=554). Catheter ablation vs. Map guided surgery was evaluated on VT/VF recurrences (p=< 0.01). Nonpharmacological techniques for VT/VF resulted in low sudden death rates (3-6%), but VT/VF recurrences were more frequent after catheter ablation (57%) than map-guided surgery (18%, P<0.01).
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