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March 30, 2023Frontiers in Sports and Active LivingOpen Access

Appropriate measurement of objective fatigability and autonomic dysfunction is crucial for understanding the etiology of chronic fatigue and personalizing exercise interventions in clinical populations.

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Why the study?

Little is known about the etiology of chronic fatigue, and conventional single-joint isometric tests fail to evaluate objective fatigability and autonomic dysfunction in ecological situations.

Design

Review article

Key result

Appropriate measurement of objective fatigability and autonomic dysfunction is crucial for understanding the etiology of chronic fatigue and personalizing exercise interventions in clinical populations.

Authors

GMGuillaume Y. MilletMBMathilde Fiona BertrandTLThomas Lapole

Discussion

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Overview

Hypothesis-generating for fatigue management; leaves open prospective validation before guiding interventions.

Structured PICO

P
Population
Clinical populations suffering from chronic fatigue (including patients with cancer, multiple sclerosis, inflammatory bowel diseases, rheumatic diseases, chronic kidney disease, chronic venous disease, and ICU survivors).
I
Intervention
Measurement of objective fatigability (using dynamic, large muscle mass protocols such as cycling or the quadriceps intermittent fatigue test) and autonomic nervous system (ANS) dysfunction (using heart rate variability, baroreflex sensitivity, and cardiopulmonary exercise testing).

Appropriate, ecologically valid measurement of objective fatigability and autonomic dysfunction is crucial for understanding the multifactorial nature of chronic fatigue and personalizing physical activity interventions.

Limitations

  • Experimental evidence showing impaired resistance to objective fatigability in patients with chronic diseases is relatively scarce.
  • Optimal conditions under which physical activity is likely to reduce fatigue remain debated.

Cite This Study

Millet et al. (2023) conducted a review in Chronic fatigue. Measurement of objective fatigability and autonomic dysfunction was evaluated. Appropriate measurement of objective fatigability and autonomic dysfunction is crucial for understanding the etiology of chronic fatigue and personalizing exercise interventions in clinical populations.

synapsesocial.com/papers/6a217f26582b7ad9ebabc0cehttps://doi.org/10.3389/fspor.2023.1140833
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Editorial: Fatigue: physiology and pathology2024
  2. 2Frontier studies on fatigue, autonomic nerve dysfunction, and sleep-rhythm disorder2015 · 106 citations
  3. 3The Relationship Between Subjective and Objective Fatigue Assessment Approaches in Multiple Sclerosis: A Meta-Analysis2026
  4. 4Autonomic nervous alterations associated with daily level of fatigue2011 · 92 citations
  5. 5The aetiopathogenesis of fatigue: unpredictable, complex and persistent2016 · 18 citations