Key result
Ivabradine, in contrast with atenolol, did not impede the shortening of left ventricular relaxation time during exercise (15 +/- 2 ms vs 23 +/- 2 ms) for a similar heart rate reduction.
Why the study?
Does ivabradine compared to atenolol affect left ventricular relaxation during exercise in dogs?
Does ivabradine compared to atenolol affect left ventricular relaxation during exercise in dogs?
Absolute Event Rate: 15% vs 23%
In a canine model, ivabradine reduces heart rate without the negative lusitropic effects on left ventricular relaxation seen with atenolol during exercise.
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Hypothesis-generating for lusitropic differences in canines; should not yet inform clinical beta-blocker choices.
Colin et al. (2002) studied this question. Ivabradine vs. Atenolol and saline was evaluated on Rate and extent of LV relaxation (time constant tau(BF), pressure asymptote P(BF)). Ivabradine, in contrast with atenolol, did not impede the shortening of left ventricular relaxation time during exercise (15 +/- 2 ms vs 23 +/- 2 ms) for a similar heart rate reduction.
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