Key result
Ivabradine and atenolol reduced myocardial oxygen consumption during exercise compared to saline (6.7 and 4.7 vs. 8.1 ml/min, P < 0.05) in instrumented dogs.
Why the study?
Do atenolol and ivabradine reduce myocardial oxygen consumption during exercise in instrumented dogs?
Do atenolol and ivabradine reduce myocardial oxygen consumption during exercise in instrumented dogs?
Absolute Event Rate: 6.7% vs 8.1%
p-value: p=<0.05
Heart rate reduction and negative inotropy equally contribute to reducing myocardial oxygen consumption during exercise, with negative inotropy limiting the increase in diastolic time afforded by heart rate reduction.
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Equal contributions of HR reduction and negative inotropy to lower exercise MVO2 shown in dogs; leaves open human translation.
Colin et al. (2003) studied Normal heart (animal model) (n=8). Atenolol or ivabradine vs. Saline was evaluated on Myocardial oxygen consumption (MVo2) (p=<0.05). Ivabradine and atenolol reduced myocardial oxygen consumption during exercise compared to saline (6.7 and 4.7 vs. 8.1 ml/min, P < 0.05) in instrumented dogs.
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