What question did this study set out to answer?

This study aims to compare the effects of atenolol and ivabradine on postsystolic wall thickening during heart rate reduction.

December 18, 2006British Journal of PharmacologyOpen Access

Heart rate reduction by inhibition of If or by β‐blockade has different effects on postsystolic wall thickening

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Why the study?

Does atenolol or ivabradine alter postsystolic wall thickening in conscious dogs?

Key Points

This study aims to compare the effects of atenolol and ivabradine on postsystolic wall thickening during heart rate reduction.
Sonomicrometry measured wall thickening in six conscious dogs at rest and during exercise after saline, atenolol (1 mg/kg), or ivabradine (1 mg/kg) administration.
Heart rate response and changes in wall thickening were compared at rest and during exercise.
Atenolol and ivabradine reduced heart rate by about 10-20% at rest and 30% during exercise compared to saline.
Atenolol increased postsystolic wall thickening at rest (0.35±0.07 vs 0.21±0.03 mm) and during exercise (0.30±0.04 vs 0.15±0.04 mm), while ivabradine did not alter PSWT.
Atenolol increased the ratio of postsystolic to systolic wall thickening by 80±23%, associated with impaired left ventricular relaxation.

Structured PICO

Does atenolol or ivabradine alter postsystolic wall thickening in conscious dogs?

Population

Six dogs prepared to measure wall thickening by sonomicrometry in the conscious state

Intervention

Atenolol (1 mg.kg-1) or ivabradine (1 mg.kg-1)

Comparator

Saline

Outcome

Postsystolic wall thickening (PSWT) at rest and during exercisesurrogate

In a canine model, heart rate reduction with ivabradine preserves systolic wall thickening without increasing wasted postsystolic effort, unlike atenolol.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Should not yet influence atenolol or ivabradine use in patients; hypothesis-generating for differential effects on wall mechanics in humans.

Cite This Study

Lucats et al. (2006) studied this question.

synapsesocial.com/papers/6a218113cdf8429e7e5fbf7b https://doi.org/10.1038/sj.bjp.0706996

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Implication

Should not yet influence atenolol or ivabradine use in patients; hypothesis-generating for differential effects on wall mechanics in humans.

Heart rate reduction by inhibition of If or by β‐blockade has different effects on postsystolic wall thickening

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Heart rate reduction by inhibition of If or by β‐blockade has different effects on postsystolic wall thickening

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider